A. S. Trigos

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

This study shows that inhibiting mutant IDH1 in AML promotes leukemic stem cell cycling and sensitizes the disease to azacitidine, suggesting a combination therapy approach.

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

This study shows that Cystathionine-β-synthase (CBS) maintains AKT-induced senescence and suppresses gastric cancer growth in PI3K/AKT-activated cells.

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

The paper shows that combining CX-5461 with pathway inhibitors improves efficacy by suppressing metabolic regulators, but resistance arises through translational re-wiring and cAMP pathway activation in blood cancers.

RNA binding kinase UHMK1 regulates therapy induced metabolic adaptation in BRAFV600 melanoma

The paper identifies UHMK1 as a regulator of metabolic adaptation in BRAFV600 melanoma under targeted therapy, showing its role in mRNA transport and translation and its impact on therapy resistance.

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

This study shows CX-5461, an RNA polymerase I inhibitor, enhances PARP inhibitor efficacy in HR-deficient HGSOC by inducing replication stress and DNA damage, overcoming resistance mechanisms.

Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer

The paper identifies somatic mutations in early metazoan genes that disrupt regulatory links between unicellular and multicellular genes in cancer, linking these mutations to drug response.

Collateral sensitivity to β-lactam drugs in drug-resistant tuberculosis is driven by the transcriptional wiring of BlaI operon genes