Author

A. J. Pruijssers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:virus· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

L. J. Stevens· 3 shared M. R. Denison· 3 shared X. Lu· 3 shared A. S. George· 2 shared D. P. Porter· 2 shared J. D. Chappell· 2 shared J. Gribble· 2 shared J. K. Perry· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

L. J. Stevens

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir

L. J. Stevens, A. J. Pruijssers, H. W. Lee, C. J. Gordon, E. P. Tchesnokov, J. Gribble, A. S. George, T. M. Hughes, X. Lu, J. Li, J. K. Perry, D. P. Porter, T. Cihlar, T. P. Sheahan, R. S. Baric, , M. R. Denison

This study identifies distinct mutations in SARS-CoV-2's RdRp that confer remdesivir resistance, showing their biochemical mechanisms and transferability to other coronaviruses.

bioRxiv · Jan 25, 2022 · PreprintMicrobiology

Neuron-intrinsic NF-κB Signaling Mediates Reovirus Virulence

T. Dermody, A. J. Pruijssers, G. M. Taylor, P. Brigleb, P. Shang, K. Urbanek, J. Brwon

This study shows that neuron-intrinsic NF-κB signaling is critical for reovirus-induced neuronal apoptosis and virulence in mice.

bioRxiv · Aug 5, 2020 · PreprintMicrobiology

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

A. J. Pruijssers, A. S. George, A. Schäfer, S. R. Leist, L. E. Gralinski, K. H. Dinnon, B. L. Yount, M. L. Agostini, L. J. Stevens, J. D. Chappell, X. Lu, T. M. Hughes, K. L. Gully, D. R. Martinez, A. J. Brown, , T. P. Sheahan

This study shows remdesivir effectively inhibits SARS-CoV-2 in human cells and mice, reducing viral load and improving lung function.

bioRxiv · Apr 27, 2020Microbiology

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

J. Gribble, A. J. Pruijssers, M. L. Agostini, J. Anderson-Daniels, J. D. Chappell, X. Lu, L. J. Stevens, A. L. Routh, M. R. Denison

This study shows that the coronavirus proofreading exoribonuclease nsp14-ExoN is essential for RNA recombination and generates defective viral genomes.

bioRxiv · Apr 23, 2020Microbiology