Author

E. R. Abt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. G. Radu· 2 shared T. M. Le· 2 shared A. Ribas· 1 shared C.-C. Chen· 1 shared D. Cheng· 1 shared D. Shackelford· 1 shared F. N. Esedebe· 1 shared G. A. Dibernardo· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

C. G. Radu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PGC-1a drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity

G. Varuzhanyan, C.-C. Chen, J. Freeland, T. He, W. Tran, K. Song, L. Wang, D. Cheng, S. Xu, G. A. Dibernardo, F. N. Esedebe, V. Bhatia, M. Han, E. R. Abt, J. W. Park, , O. N. Witte

bioRxiv · Apr 9, 2024Cancer Biology

Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation

V. Winstel, E. R. Abt, T. M. Le, C. G. Radu

The paper shows that inhibiting host deoxycytidine kinase with (R)-DI-87 reduces Staphylococcus aureus abscess formation by protecting phagocytes and enhancing immune response.

bioRxiv · Aug 18, 2023 · PreprintMicrobiology

Defective Nucleotide Catabolism Defines a Subset of Cancers Sensitive to Purine Nucleoside Phosphorylase Inhibition

E. R. Abt, V. Lok, T. M. Le, S. Poddar, W. Kim, J. R. Capri, G. Abril-Rodriguez, T. R. Donahue, J. Czernin, T. Mehrling, A. Ribas, C. G. Radu

This study identifies SAMHD1, dCK, and CDA as biomarkers for predicting sensitivity to PNP inhibitors in cancers, showing that PNP inhibition can target both hematological and solid tumors.

bioRxiv · Nov 4, 2019 · PreprintCancer Biology