Author

T. M. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. G. Radu· 2 shared E. R. Abt· 2 shared A. Fiebig· 1 shared A. Ribas· 1 shared A. Tajima· 1 shared C. E. Vrentas· 1 shared D. T. Nguyen· 1 shared G. Abril-Rodriguez· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

C. G. Radu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation

V. Winstel, E. R. Abt, T. M. Le, C. G. Radu

The paper shows that inhibiting host deoxycytidine kinase with (R)-DI-87 reduces Staphylococcus aureus abscess formation by protecting phagocytes and enhancing immune response.

bioRxiv · Aug 18, 2023 · PreprintMicrobiology

The ATF6β-calreticulin axis protects hippocampal neurons against endoplasmic reticulum stress and excitotoxicity

D. T. Nguyen, T. M. Le, T. Hattori, M. Takarada-Iemata, H. Ishii, J. Roboon, T. Tamatani, T. Kannon, K. Hosomichi, A. Tajima, S. Taniuchi, M. Miyake, S. Oyadomari, S. Saito, K. Mori, O. Hori

This study shows that ATF6β-calreticulin protects hippocampal neurons from ER stress and excitotoxicity by maintaining Ca2+ homeostasis.

bioRxiv · Feb 1, 2021Cell Biology

Quantification of Brucella abortus population structure in a natural host

A. Fiebig, C. E. Vrentas, T. M. Le, M. Huebner, P. M. Boggiatto, S. C. Olsen, S. Crosson

This study quantifies Brucella abortus population structure in cattle using barcoded strains, revealing a severe bottleneck limiting colonization of lymph nodes.

bioRxiv · Nov 12, 2020Microbiology

Defective Nucleotide Catabolism Defines a Subset of Cancers Sensitive to Purine Nucleoside Phosphorylase Inhibition

E. R. Abt, V. Lok, T. M. Le, S. Poddar, W. Kim, J. R. Capri, G. Abril-Rodriguez, T. R. Donahue, J. Czernin, T. Mehrling, A. Ribas, C. G. Radu

This study identifies SAMHD1, dCK, and CDA as biomarkers for predicting sensitivity to PNP inhibitors in cancers, showing that PNP inhibition can target both hematological and solid tumors.

bioRxiv · Nov 4, 2019 · PreprintCancer Biology

The sustained release of basic fibroblast growth factor accelerates angiogenesis and the survival of the inactivated dermis by high hydrostatic pressure

T. M. Le, N. Morimoto, T. Mitsui, S. C. Notodihardjo, M. C. Munisso, N. Kakudo, K. Kusumoto

This study shows that sustained release of basic fibroblast growth factor via collagen/gelatin sponge improves angiogenesis and survival of inactivated dermis in skin grafts.

bioRxiv · Nov 22, 2018Bioengineering