Author

E. R. May

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

H. H. Szeto· 2 shared N. N. Alder· 2 shared W. Mitchell· 2 shared A. Alexandrescu· 1 shared A. Coscia· 1 shared A. G. Feinstein· 1 shared A. K. Jana· 1 shared B. Saha· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

H. H. Szeto

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The αC helix is a central regulator of PKR activation

A. G. Feinstein, J. L. Cole, E. R. May

This study investigates the structural mechanism of PKR activation, showing that back-to-back dimerization stabilizes a catalytically competent conformation through the C helix.

bioRxiv · Apr 30, 2024 · PreprintBiophysics

Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant

N. Senoo, D. K. Chinthapalli, M. G. Baile, V. K. Golla, B. Saha, O. B. Ogunbona, J. A. Saba, T. Munteanu, Y. Valdez, K. Whited, D. Chorev, N. Alder, E. R. May, C. V. Robinson, S. M. Claypool

This study investigates the role of cardiolipin interactions in the ADP/ATP carrier using yeast Aac2, showing that disrupting these interactions impairs structure and transport activity, with clinical relevance in ANT1 mutations.

bioRxiv · May 5, 2023Biochemistry

Structure-Activity Relationships in the Design of Mitochondria-Targeted Peptide Therapeutics

W. Mitchell, J. Tamucci, E. Ng, S. Liu, H. H. Szeto, E. R. May, A. Alexandrescu, N. N. Alder

This study analyzes structure-activity relationships of mitochondria-targeted tetrapeptides, finding that side chain composition and sequence register significantly affect their efficacy and membrane interactions.

bioRxiv · Nov 8, 2021 · PreprintBiochemistry

Atomistic Dynamics of a Viral Infection Process: Release of Membrane Lytic Peptides from a Non-Enveloped Virus

A. K. Jana, E. R. May

This study uses molecular simulations to investigate the pH-dependent release of membrane lytic peptides from Flock House Virus, revealing nanoscopic details of the mechanism.

bioRxiv · Jan 7, 2021Biophysics

Molecular Mechanism of Action of Mitochondrial Therapeutic SS-31 (Elamipretide): Membrane Interactions and Effects on Surface Electrostatics

W. Mitchell, E. A. Ng, J. D. Tamucci, K. Boyd, M. Sathappa, A. Coscia, M. Pan, X. Han, N. A. Eddy, E. R. May, H. H. Szeto, N. N. Alder

This paper investigates how SS-31 interacts with mitochondrial membranes, showing it modulates surface electrostatics and lipid packing, supporting its mitoprotective mechanism.

bioRxiv · Aug 14, 2019 · PreprintBiophysics