Author

S. M. Claypool

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:differential expression· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2

Frequent Co-Authors

M. G. Acoba· 2 shared N. Senoo· 2 shared Y.-W. Lu· 2 shared A. Anzmann· 1 shared A. Barrientos· 1 shared A. Crocker· 1 shared A. D. Gregory· 1 shared A. Gokhale· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

M. G. Acoba

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Stem cell models of TAFAZZIN deficiency reveal novel tissue-specific pathologies in Barth Syndrome

O. S. Carney, K. W. Harris, Y. Wohlfarter, K. Lee, G. Butschek, A. Anzmann, S. M. Claypool, A. Hamacher-Brady, M. A. Keller, H. J. Vernon

This study uses stem cell models to investigate tissue-specific pathologies in Barth Syndrome caused by TAFAZZIN deficiency, identifying mitophagy defects and potential therapeutic targets.

bioRxiv · Apr 28, 2024Cell Biology

Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant

N. Senoo, D. K. Chinthapalli, M. G. Baile, V. K. Golla, B. Saha, O. B. Ogunbona, J. A. Saba, T. Munteanu, Y. Valdez, K. Whited, D. Chorev, N. Alder, E. R. May, C. V. Robinson, S. M. Claypool

This study investigates the role of cardiolipin interactions in the ADP/ATP carrier using yeast Aac2, showing that disrupting these interactions impairs structure and transport activity, with clinical relevance in ANT1 mutations.

bioRxiv · May 5, 2023Biochemistry

APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

M. E. Wynne, O. Ogunbona, A. R. Lane, A. Gokhale, S. A. Zlatic, C. Xu, Z. Wen, D. Duong, S. Rayaprolu, A. Ivanova, E. A. Ortlund, E. B. Dammer, N. T. Seyfried, B. R. Roberts, A. Crocker, , V. Faundez

This study shows mitochondrial dysfunction increases APOE expression and secretion in multiple cell types and models, linking mitochondrial health to Alzheimer's disease risk.

bioRxiv · May 11, 2022Cell Biology

Impaired phosphatidylethanolamine metabolism activates a reversible stress response that detects and resolves mutant mitochondrial precursors

P. Sam, E. Calzada, M. G. Acoba, T. Zhao, Y. Watanabe, A. Nejatfard, J. Trinidad, T. Shutt, S. E. Neal, S. M. Claypool

The paper investigates the subcellular localization of Psd1 and shows that impaired phosphatidylethanolamine metabolism triggers an ER-assisted response to resolve nonfunctional mitochondrial precursors.

bioRxiv · Dec 10, 2020Cell Biology

The mitochondrial carrier SFXN1 is critical for Complex III integrity and cellular metabolism

M. G. Acoba, E. S. S. Alpergin, S. Renuse, L. Fernandez-del-Rio, Y.-W. Lu, C. F. Clarke, A. Pandey, M. J. Wolfgang, S. M. Claypool

This study identifies SFXN1 as critical for Complex III integrity and cellular metabolism through its role in heme and central carbon metabolism, independent of its known function as a serine transporter.

bioRxiv · Jun 18, 2020Biochemistry

Adenine Nucleotide Translocase regulates the airway epithelium, mitochondrial metabolism and ciliary function

C. Kliment, J. M. K. Nguyen, M. J. Kaltreider, Y.-W. Lu, S. M. Claypool, J. E. Radder, F. C. Sciurba, Y. Zhang, A. D. Gregory, P. A. Iglesias, V. K. Sidhaye, D. N. Robinson

This study identifies Adenine Nucleotide Translocase (ANT) as a protective factor against cigarette smoke in lung cells, showing its role in mitochondrial metabolism, airway hydration, and ciliary function in COPD.

bioRxiv · May 18, 2020 · PreprintCell Biology