Mechanism of dual pharmacological correction and potentiation of human CFTR
C. Wang, Z. Yang, B. J. Loughlin, H. Xu, G. Veit, S. Vorobiev, O. B. Clarke, F. Jiang, Y. Li, S. Singh, Z. Rich, E. R. Menten, R. A. Grassucci, W. Wang, A. Mezzell, , J. F. Hunt
This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.
bioRxiv · Oct 10, 2022 · PreprintBiophysics