Author

A. L. B. Pyne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Assay:imaging· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

B. W. Hoogenboom· 3 shared J. G. Beton· 2 shared A. D. Bates· 1 shared A. dos Santos· 1 shared A. Maxwell· 1 shared A. Menny· 1 shared A. Noy· 1 shared A. P. Joseph· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

B. W. Hoogenboom

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Author profile →

6 papers

Recent·Most cited

Complement-mediated killing of bacteria by mechanical destabilization of the cell envelope

G. Benn, C. Bortolini, D. M. Roberts, A. L. B. Pyne, S. Holden, B. W. Hoogenboom

The paper uses atomic force microscopy to study how MAC pores in E. coli lead to mechanical destabilization of the cell envelope, causing lysis through inner membrane permeation.

bioRxiv · Dec 10, 2023Microbiology

Autophagy receptor NDP52 alters DNA conformation to modulate RNA Polymerase II transcription

A. dos Santos, D. E. Rollins, Y. Hari-Gupta, H. C. Reed, M. Du, S. Y. Z. Ru, K. Pidlisna, A. Stranger, F. Lorgat, I. Brown, K. Howland, J. Arron, L. Wang, P. J. Ellis, T. L. Chew, , C. P. Toseland

This study identifies NDP52's role in modulating RNA Polymerase II transcription by altering DNA conformation through direct dsDNA binding and interactions with chromatin regulators.

bioRxiv · Feb 1, 2022 · PreprintBiophysics

Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides

A. L. B. Pyne, A. Noy, K. Main, V. Velasco-Berrelleza, M. M. Piperakis, L. A. Mitchenhall, F. M. Cugliandolo, J. G. Beton, C. E. M. Stevenson, B. W. Hoogenboom, A. D. Bates, A. Maxwell, S. A. Harris

This study uses AFM and MD simulations to analyze how DNA supercoiling affects structure and triplex-forming oligonucleotide binding at base-pair resolution.

bioRxiv · Jan 7, 2021Biophysics

TopoStats - a program for automated tracing of biomolecules from AFM images

J. G. Beton, R. Moorehead, L. Helfmann, R. Gray, B. Hoogenboom, A. P. Joseph, M. Topf, A. L. B. Pyne

TopoStats automatically traces biomolecules in AFM images with high accuracy, identifying 90% of molecules and assemblies without prior processing.

bioRxiv · Sep 23, 2020Biophysics

Cantilever Sensors for Rapid Optical Antimicrobial Sensitivity Testing

I. Bennett, A. L. B. Pyne, R. McKendry

This paper introduces a rapid cantilever-based method to detect antibiotic resistance in bacteria within 45 minutes, using single-cell detection without bacterial immobilization.

bioRxiv · Mar 9, 2020Biophysics

Single-molecule kinetics of pore assembly by the membrane attack complex

E. S. Parsons, G. J. Stanley, A. L. B. Pyne, A. W. Hodel, A. P. Nievergelt, A. Menny, A. R. Yon, A. Rowley, R. P. Richter, G. E. Fantner, D. Bubeck, B. W. Hoogenboom

This study uses AFM to analyze MAC assembly kinetics, finding that C9 incorporation is the rate-limiting step in pore formation.

bioRxiv · Nov 16, 2018Biophysics