Author

E. S. Pringle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

C. McCormick· 3 shared B. Duguay· 2 shared D. A. Khaperskyy· 2 shared D. Falzarano· 2 shared M. Kleer· 2 shared P. D. Slaine· 2 shared S. Ying· 2 shared A. D. Balgi· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersMicrobiology

C. McCormick

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Author profile →

4 papers

Recent·Most cited

Dual inhibition of coronavirus Mpro and PLpro enzymes by phenothiazines and their antiviral activity

K. L. Forrestall, E. S. Pringle, D. Sands, B. Duguay, B. Farewell, T. Woldemariam, D. Falzarano, I. R. Pottie, C. McCormick, S. Darvesh

This paper identifies a phenothiazine urea derivative that inhibits both SARS-CoV-2 Mpro and PLpro proteases and shows broad antiviral activity against multiple human coronaviruses.

bioRxiv · Sep 11, 2023 · PreprintMicrobiology

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

E. S. Pringle, B. A. Duguay, M. P. Bui-Marinos, R. P. Mulloy, S. L. Landreth, K. S. Desireddy, S. M. Dolliver, S. Ying, T. Caddell, P. D. Slaine, S. L. Bearne, D. Falzarano, J. Corcoran, D. A. Khaperskyy, C. McCormick

This paper shows that thiopurines inhibit coronavirus replication by disrupting Spike protein processing and incorporation into virions.

bioRxiv · Mar 10, 2022Microbiology

A panel of KSHV mutants in the polycistronic kaposin locus for precise analysis of individual protein products

M. Kleer, G. MacNeil, E. S. Pringle, J. A. Corcoran

The paper creates a panel of KSHV mutants to analyze the individual roles of kaposin proteins in viral replication and pathogenesis.

bioRxiv · Jun 11, 2021Microbiology

Thiopurines activate an antiviral unfolded protein response that blocks viral glycoprotein accumulation in cell culture infection model

P. D. Slaine, M. Kleer, B. Duguay, E. S. Pringle, E. Kadijk, S. Ying, A. D. Balgi, M. Roberge, C. McCormick, D. A. Khaperskyy

This study shows that thiopurines 6-TG and 6-TGo activate the UPR to block viral glycoprotein accumulation in cell culture models of influenza and coronavirus infections.

bioRxiv · Sep 30, 2020Microbiology