C. McCormick

Dual inhibition of coronavirus Mpro and PLpro enzymes by phenothiazines and their antiviral activity

This paper identifies a phenothiazine urea derivative that inhibits both SARS-CoV-2 Mpro and PLpro proteases and shows broad antiviral activity against multiple human coronaviruses.

30-Minute Highly Multiplexed VaxArray Immunoassay for Pneumococcal Vaccine Antigen Characterization

The paper introduces a 30-minute multiplexed immunoassay for identifying and quantifying pneumococcal vaccine antigens with high specificity and precision.

Synthesis of Long RNA with a Site-Specific Modification by Enzymatic Splint Ligation

This paper improves the synthesis of long RNA with site-specific modifications using enzymatic splint ligation by addressing structural and sequence heterogeneity.

Rapid Identity and Quantity CQA Test for Multivalent mRNA Drug Product Formulations

This paper demonstrates a multiplexed platform for rapid identity verification and concentration determination of mRNA formulations, achieving high specificity and sensitivity without PCR or mRNA extraction.

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

This paper shows that thiopurines inhibit coronavirus replication by disrupting Spike protein processing and incorporation into virions.

VaxArray Immunoassay for the Multiplexed Quantification of Poliovirus D-Antigen

The paper develops a multiplexed immunoassay for rapid and accurate quantification of poliovirus D-antigen across all three serotypes, improving upon traditional ELISA methods.

A new phylodynamic model of Mycobacterium bovis transmission in a multi-host system uncovers the role of the unobserved reservoir.

This paper develops a phylodynamic model to study M. bovis transmission in a multi-host system, finding that a hidden reservoir contributes to local infections without generating pathogen diversity.

Thiopurines activate an antiviral unfolded protein response that blocks viral glycoprotein accumulation in cell culture infection model

This study shows that thiopurines 6-TG and 6-TGo activate the UPR to block viral glycoprotein accumulation in cell culture models of influenza and coronavirus infections.

Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins

This paper shows that defective influenza A virus RNAs trigger MAVS-dependent upregulation of HLA class I proteins, which may aid viral evasion of innate immunity.

Rhinovirus 2A is the predominant protease responsible for instigating the early block to gene expression encountered in infected cells

This study compares the ability of rhinovirus 2A and 3C proteases to suppress host gene expression and finds that 2A acts more rapidly.

The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression

This study identifies PA-X, an influenza A virus protein, as a factor that selectively targets host mRNAs for degradation by hijacking RNA splicing machinery.

KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication

Stress granule-inducing eukaryotic translation initiation factor 4A inhibitors block influenza A virus replication

This paper shows that eIF4A inhibitors like PatA and silvestrol block influenza A virus replication by inducing stress granules and inhibiting viral protein synthesis.