D. A. Khaperskyy

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

This paper shows that thiopurines inhibit coronavirus replication by disrupting Spike protein processing and incorporation into virions.

Thiopurines activate an antiviral unfolded protein response that blocks viral glycoprotein accumulation in cell culture infection model

This study shows that thiopurines 6-TG and 6-TGo activate the UPR to block viral glycoprotein accumulation in cell culture models of influenza and coronavirus infections.

Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins

This paper shows that defective influenza A virus RNAs trigger MAVS-dependent upregulation of HLA class I proteins, which may aid viral evasion of innate immunity.

The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression

This study identifies PA-X, an influenza A virus protein, as a factor that selectively targets host mRNAs for degradation by hijacking RNA splicing machinery.

Stress granule-inducing eukaryotic translation initiation factor 4A inhibitors block influenza A virus replication

This paper shows that eIF4A inhibitors like PatA and silvestrol block influenza A virus replication by inducing stress granules and inhibiting viral protein synthesis.