Author

P. D. Slaine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

C. McCormick· 4 shared D. A. Khaperskyy· 4 shared E. S. Pringle· 2 shared M. Kleer· 2 shared S. Ying· 2 shared A. A. Kelvin· 1 shared A. D. Balgi· 1 shared A. P. Makrigiannis· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersMicrobiology

C. McCormick

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Author profile →

4 papers

Recent·Most cited

Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

E. S. Pringle, B. A. Duguay, M. P. Bui-Marinos, R. P. Mulloy, S. L. Landreth, K. S. Desireddy, S. M. Dolliver, S. Ying, T. Caddell, P. D. Slaine, S. L. Bearne, D. Falzarano, J. Corcoran, D. A. Khaperskyy, C. McCormick

This paper shows that thiopurines inhibit coronavirus replication by disrupting Spike protein processing and incorporation into virions.

bioRxiv · Mar 10, 2022Microbiology

Thiopurines activate an antiviral unfolded protein response that blocks viral glycoprotein accumulation in cell culture infection model

P. D. Slaine, M. Kleer, B. Duguay, E. S. Pringle, E. Kadijk, S. Ying, A. D. Balgi, M. Roberge, C. McCormick, D. A. Khaperskyy

This study shows that thiopurines 6-TG and 6-TGo activate the UPR to block viral glycoprotein accumulation in cell culture models of influenza and coronavirus infections.

bioRxiv · Sep 30, 2020Microbiology

Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins

M. M. A. Rahim, B. Parsons, E. L. Price, P. D. Slaine, B. L. Chilvers, G. S. Seaton, A. Wight, S. Dey, S. L. Grandy, L. E. Anderson, N. Zamorano Cuervo, N. Grandvaux, M. M. Gaglia, A. A. Kelvin, D. A. Khaperskyy, , A. P. Makrigiannis

This paper shows that defective influenza A virus RNAs trigger MAVS-dependent upregulation of HLA class I proteins, which may aid viral evasion of innate immunity.

Journal of Virology · Jun 16, 2020Peer-reviewedMicrobiology

Stress granule-inducing eukaryotic translation initiation factor 4A inhibitors block influenza A virus replication

P. D. Slaine, M. Kleer, N. Smith, D. A. Khaperskyy, C. McCormick

This paper shows that eIF4A inhibitors like PatA and silvestrol block influenza A virus replication by inducing stress granules and inhibiting viral protein synthesis.

bioRxiv · Oct 2, 2017Microbiology