A lysosomal lipid transport pathway that enables cell survival under cholinelimitation
S. G. Scharenberg, W. Dong, K. Nyame, R. Levin-Konigsberg, A. R. Krishnan, E. S. Rawat, K. Spees, M. C. Bassik, M. Abu-Remaileh
This study identifies SPNS1 as a critical lysosomal transporter for choline recycling under limitation, revealing a novel pathway for phospholipid salvage and cell survival.
bioRxiv · Nov 27, 2022 · PreprintCell Biology