Author

K. Spees

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

M. C. Bassik· 2 shared R. Levin-Konigsberg· 2 shared A. Colville· 1 shared A. Goshayeshi· 1 shared A. Kundaje· 1 shared A. Nigam· 1 shared A. R. Krishnan· 1 shared D. W. Morgens· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

M. C. Bassik

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

SLC12A9 is a lysosome-detoxifying ammonium - chloride co-transporter

R. Levin-Konigsberg, K. Mitra, A. Nigam, K. Spees, P. Hivare, K. Liu, A. Kundaje, Y. Krishnan, M. Bassik

This study identifies SLC12A9 as a lysosomal ammonium exporter that maintains lysosomal homeostasis by transporting ammonium and chloride.

bioRxiv · May 22, 2023 · PreprintCell Biology

A lysosomal lipid transport pathway that enables cell survival under cholinelimitation

S. G. Scharenberg, W. Dong, K. Nyame, R. Levin-Konigsberg, A. R. Krishnan, E. S. Rawat, K. Spees, M. C. Bassik, M. Abu-Remaileh

This study identifies SPNS1 as a critical lysosomal transporter for choline recycling under limitation, revealing a novel pathway for phospholipid salvage and cell survival.

bioRxiv · Nov 27, 2022 · PreprintCell Biology

Death-seq identifies regulators of cell death and senolytic therapies

A. Colville, J.-Y. Liu, S. Thomas, H. D. Ishak, R. Zhou, J. D. D. Klein, D. W. Morgens, A. Goshayeshi, J. S. Salvi, D. Yao, K. Spees, M. C. Bassik, T. A. Rando

Death-seq identifies enhancers of cell death and senolytic therapies through a CRISPR screen, revealing synergistic combinations that clear senescent cells without thrombocytopenia.

bioRxiv · Apr 1, 2022Cell Biology