E. Schwartz

Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers Skp2 function in metastasis, genomic instability and immune activation and reveals additional target pathways

This study uses scRNA-seq to analyze murine osteosarcoma models and identifies Skp2's role in metastasis, genomic instability, and immune activation, revealing potential therapeutic targets.

SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis

This study shows SKP2 knockout in osteosarcoma mouse models increases immune infiltration and correlates with improved patient survival.

Edaphic controls on genome size and GC content of bacteria in soil microbial communities

The paper uses soil metagenomes to show that pH, soil carbon content, and nutrient availability influence bacterial genome size, GC content, and amino acid composition.

Soil, ocean, hot spring, and host-associated environments reveal unique selection pressures on genomic features of bacteria in microbial communities

The paper analyzes genomic features of bacteria across different environments, finding that genome size, GC content, and sigma-factor abundance vary with ecosystem type and environmental constraints.

Rapid response of nitrogen cycling gene transcription to labile carbon amendments in a soil microbial community

This study shows that soil microbial communities rapidly alter transcription of nitrogen cycling genes in response to labile carbon amendments.

The Functional Significance of Bacterial Predators

This study quantifies the growth and carbon assimilation rates of predatory bacteria across 15 sites, showing obligate predators grow faster and assimilate more carbon than non-predatory bacteria.

Characterization of a new Leishmania major isolate for use in a controlled human infection model

This paper isolates and characterizes a new Leishmania major strain for use in controlled human infection models to advance vaccine development.

Measurement error and resolution in quantitative stable isotope probing: implications for experimental design

This paper evaluates measurement error and resolution in qSIP, finding that variance decreases with taxon abundance and that nine density fractions balance cost and precision.