Author

J. Sadlova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cell Biology· 2 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 5 Research Focus:cell type annotation· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

P. Volf· 10 shared B. Vojtkova· 7 shared F. Moreira-Leite· 3 shared K. Pruzinova· 3 shared R. Yanase· 3 shared T. Becvar· 3 shared A. Taniguchi· 2 shared E. Rea· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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10 shared papersMicrobiology

P. Volf

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10 papers

Recent·Most cited

Steppe lemmings and Chinese hamsters as new potential animal models for the study of the leishmania subgenus Mundinia (Kinetoplastida: Trypanosomatidae)

T. Becvar, B. Vojtkova, L. Pacakova, B. Vomackova Kykalova, L. Ticha, P. Volf, J. Sadlova

This study identifies Chinese hamsters and Steppe lemmings as new animal models for studying Mundinia Leishmania species, showing susceptibility and infectiousness to sand flies.

bioRxiv · Jan 2, 2024 · PreprintMicrobiology

3D electron microscopy of the Leishmania mexicana cell cycle: Patterns of organelle duplication and segregation and their implications for parasite biology

M. Hair, R. Yanase, F. Moreira-Leite, R. J. Wheeler, J. Sadlova, P. Volf, S. Vaughan, J. Sunter

This study uses 3D electron microscopy to analyze Leishmania mexicana cell cycle stages, revealing organelle duplication, segregation patterns, and metabolic adaptations in different environments.

bioRxiv · Nov 28, 2023 · PreprintCell Biology

Discovery of essential kinetoplastid-insect adhesion proteins and their function in Leishmania-sand fly interactions

R. Yanase, K. Pruzinova, E. Rea, F. Moreira-Leite, A. Taniguchi, S. Nonaka, J. Sadlova, B. Vojtkova, P. Volf, J. Sunter

The paper identifies kinetoplastid-insect adhesion proteins (KIAPs) involved in Leishmania-sand fly interactions and shows their role in adhesion and colonization.

bioRxiv · Sep 29, 2023 · PreprintMicrobiology

Formation and three-dimensional architecture of Leishmania adhesion in the sand fly vector

R. Yanase, F. Moreira-Leite, E. Rea, L. Wilburn, J. Sadlova, B. Vojtkova, K. Pruzinova, A. Taniguchi, S. Nonaka, P. Volf, J. D. Sunter

This study uses 3D electron microscopy to analyze the structure and adhesion mechanisms of Leishmania haptomonads in sand flies, identifying key stages and the role of calcium in attachment.

bioRxiv · Oct 28, 2022Microbiology

Leishmania allelic selection during experimental sand fly infection correlates with mutational signatures of oxidative DNA damage

G. Bussotti, B. Li, P. Pescher, B. Vojtkova, I. Louradour, K. Pruzinova, J. Sadlova, P. Volf, G. F. Spaeth

This study identifies oxidative DNA damage signatures in Leishmania donovani during sand fly infection, linking them to allelic and haplotype selection through genomic analysis.

bioRxiv · May 2, 2022Evolutionary Biology

Experimental evolution reveals post-transcriptional regulation as a novel driver of Leishmania fitness gain

L. Piel, K. S. Rajan, G. Bussotti, H. Varet, R. Legendre, C. Proux, T. Douche, Q. Giai Gianetto, T. Chaze, T. Cokelaer, B. Vojtkova, N. Gordon-Bar, T. Doniger, S. Cohen-Chalamish, P. Rengaraj, , G. F. Spaeth

This study shows that post-transcriptional regulation, not just genome instability, drives fitness gain in Leishmania parasites during in vitro adaptation.

bioRxiv · Mar 22, 2021 · PreprintMicrobiology

Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival

N. Baker, C. M. C. Catta-Preta, R. Neish, J. Sadlova, B. Powell, E. V. C. Alves-Ferreira, V. Geohegan, J. B. T. Carnielli, K. Newling, C. Hughes, B. Vojtkova, J. Anand, A. Mihut, P. Walrad, L. G. Wilson, , J. C. Mottram

The paper systematically analyzes Leishmania protein kinases to identify those regulating differentiation and survival across life cycle stages.

bioRxiv · Sep 6, 2020Microbiology

Characterization of a new Leishmania major isolate for use in a controlled human infection model

H. Ashwin, J. Sadlova, B. Vojtkova, T. Becvar, P. Lypaczewski, E. Schwartz, E. Greensted, K. Van Bocxlaer, M. Pasin, K. Lipinski, V. Parkash, G. Matlashewski, A. Layton, C. Lacey, C. Jaffe, , P. Kaye

This paper isolates and characterizes a new Leishmania major strain for use in controlled human infection models to advance vaccine development.

bioRxiv · Aug 12, 2020Microbiology

The Phlebotomus papatasi transcriptomic response to trypanosomatid-contaminated blood is robust but non-specific

M. A. Sloan, J. Sadlova, T. Lestinova, M. Sanders, J. A. Cotton, P. Volf, P. Ligoxygakis

The paper examines the transcriptomic response of sand flies to trypanosomatid-contaminated blood, finding a generalized response to blood meals rather than specific parasite-related changes.

bioRxiv · Dec 6, 2019 · PreprintImmunology

Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections

T. Beneke, F. Demay, E. Hookway, N. Ashman, H. Jeffery, J. Smith, J. Valli, T. Becvar, J. Myskova, T. Lestinova, S. Shafiq, J. Sadlova, P. Volf, R. J. Wheeler, E. Gluenz

This study identifies flagellar proteins in Leishmania and shows that directional motility is essential for parasite colonization of sand flies.

bioRxiv · Nov 27, 2018Cell Biology