Author

K. Kostyrko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:perturbation response prediction· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. Gerlach· 2 shared M. H. Hofmann· 2 shared A. A. Machado· 1 shared A. Frank· 1 shared A. Jeschko· 1 shared A. Linke· 1 shared A. Sorokin· 1 shared B. Mair· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

D. Gerlach

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Author profile →

3 papers

Recent·Most cited

SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma

B. R. Daley, N. E. Sealover, E. Sheffels, J. M. Hughes, D. Gerlach, M. H. Hofmann, K. Kostyrko, B. Mair, A. Linke, Z. Beckley, A. Frank, C. L. Dalgard, R. L. Kortum

This study shows that SOS1 inhibition with BI-3406 enhances G12C inhibitor efficacy and delays resistance in lung adenocarcinoma by targeting resistance mechanisms and drug-tolerant persister cells.

bioRxiv · Dec 7, 2023 · PreprintCancer Biology

Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance

V. Thatikonda, H. Lu, S. Jurado, K. Kostyrko, C. A. Bristow, K. Bosch, N. Feng, S. Gao, D. Gerlach, M. Gerlach, S. Lieb, A. Jeschko, A. A. Machado, E. D. Marszalek, M. Mahendra, , M. H. Hofmann

This study shows that combining KRASG12C and SOS1 inhibitors improves anti-tumor response and delays resistance in KRASG12C-driven cancers.

bioRxiv · Jan 23, 2023Cancer Biology

Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

M. R. Kelly, K. Kostyrko, K. Han, N. Mooney, E. E. Jeng, K. L. Abbott, D. M. Gwinn, E. A. Sweet-Cordero, M. C. Bassik, P. K. Jackson

The paper identifies new RAS effector pathways and synthetic lethal interactions in lung adenocarcinoma using proteomic and genetic screening.

bioRxiv · Apr 20, 2020Cancer Biology