A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer
J. Jeong, J. Lee, S. Kim, J. Lim, J. Shin, K. Yoo, J. Kim, Y. Tanaka, H. S. Tae, L. K. Kim, I.-H. Park, J. Wysolmerski, j. choi
This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.
bioRxiv · Apr 16, 2024 · PreprintCancer Biology