E. Troemel

C. elegans RIG-I-like receptor DRH-1 signals via CARDs to activate anti-viral immunity in intestinal cells

This study identifies DRH-1 as a C. elegans RIG-I-like receptor that uses 2CARD domains to activate anti-viral immunity in intestinal cells, showing parallels with mammalian RIG-I signaling.

CUL-6/cullin ubiquitin ligase-mediated degradation of HSP-90 by intestinal lysosomes promotes thermotolerance

This study shows that CUL-6 ubiquitin ligase promotes thermotolerance by degrading HSP-90 in intestinal lysosomes, independent of HSF-1.

Impairment of the SKN-1A/NRF1 proteasome surveillance pathway triggers tissue-specific protective immune responses against distinct natural pathogens in C. elegans.

The C. elegans RIG-I homolog drh-1 mediates the Intracellular Pathogen Response upon viral infection

This paper shows that drh-1 in C. elegans mediates the Intracellular Pathogen Response (IPR) to viral infection, acting as a pattern-recognition receptor independent of its role in RNAi.

Natural variation in the roles of C. elegans autophagy components during microsporidia infection

This study investigates natural variation in C. elegans autophagy components during microsporidia infection, finding that HW strain has more efficient LGG-2 targeting to parasites but lgg-2 is not required for clearance.