Author

E. W. Harhaj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Zhang· 3 shared Y. B. Choi· 3 shared A. Garcia-Sastre· 1 shared A. Kapoor· 1 shared A. Lavorgna· 1 shared A. Pekosz· 1 shared C. C. Norbury· 1 shared C. He· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

J. Zhang

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagy

K. Shaikh, M. Bowman, S. M. McCormick, L. Gao, J. Zhang, J. Tawil, A. Kapoor, R. Arav-Boger, Y. B. Choi, A. Pekosz, S. L. Klein, M. Lanza, J. C. Fanburg-Smith, A. Garcia-Sastre, C. C. Norbury, , E. W. Harhaj

This study identifies ZFAND6 as a component of a TRAF2-cIAP E3 ubiquitin ligase complex that regulates mitophagy, maintaining mitochondrial homeostasis and influencing immune responses to viral infection.

bioRxiv · Mar 27, 2024 · PreprintImmunology

Phosphorylation of the selective autophagy receptor TAX1BP1 by canonical and noncanonical IκB kinases promotes its lysosomal localization and clearance of MAVS aggregates

Y. B. Choi, J. Zhang, M. T. Vo, J. White, C. He, E. W. Harhaj

This study shows that phosphorylation of TAX1BP1 by IκB kinases promotes its lysosomal degradation and enhances its ability to clear MAVS aggregates.

bioRxiv · Jan 7, 2021 · PreprintImmunology

The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-kB activation

E. W. Harhaj, S. Mohanty, T. Han, Y. B. Choi, A. Lavorgna, J. Zhang

This study identifies UBE4B as a host factor that ubiquitinates HTLV-1 Tax to promote NF-κB activation and cell survival in ATLL.

PLOS Pathogens · Dec 23, 2020Peer-reviewedMicrobiology