Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction
Caiwei Guo, Kuchuan Chen, Sarat C. Vatsavayai, Tetsuya Akiyama, Chang Liu, Yi Zeng, Odilia Sianto, Edith Yang, Juliane Bombosch, Rasheen Powell, Shannon Zhen, Shila Mekhoubad, Ryan D. Morrie, Georgiana Miller, Dragana Ilic, , Aaron D. Gitler
This study identifies TDP-43-dependent cryptic splicing events in synaptic and membrane excitability genes and shows they drive neuronal dysfunction in ALS and FTD.
Science Translational Medicine · Jun 3, 2026Peer-reviewedNeuroscience