Author

Shila Mekhoubad

Maze (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron D. GitleriD· 2 shared Caiwei GuoiD· 2 shared Eric M. GreeniD· 2 shared Georgiana MilleriD· 2 shared Leonard PetrucelliiD· 2 shared Sarat C. VatsavayaiiD· 2 shared Tetsuya AkiyamaiD· 2 shared William W. SeeleyiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Aaron D. GitlerORCID

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2 papers

Recent·Most cited

Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction

Caiwei Guo, Kuchuan Chen, Sarat C. Vatsavayai, Tetsuya Akiyama, Chang Liu, Yi Zeng, Odilia Sianto, Edith Yang, Juliane Bombosch, Rasheen Powell, Shannon Zhen, Shila Mekhoubad, Ryan D. Morrie, Georgiana Miller, Dragana Ilic, , Aaron D. Gitler

This study identifies TDP-43-dependent cryptic splicing events in synaptic and membrane excitability genes and shows they drive neuronal dysfunction in ALS and FTD.

Science Translational Medicine · Jun 3, 2026Peer-reviewedNeuroscience

TDP-43 represses cryptic exon inclusion in FTD/ALS gene UNC13A

X. Rosa Ma, Mercedes Prudencio, Yuka Mitsuhashi Koike, Sarat C. Vatsavayai, Garam Kım, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, Tetsuya Akiyama, Hermann Broder Schmidt, Beryl B. Cummings, David W. Wyatt, Katherine Kurylo, Georgiana Miller, , Aaron D. Gitler

This study shows that TDP-43 represses a cryptic exon in UNC13A, and genetic variants associated with FTD/ALS increase cryptic exon inclusion when TDP-43 is dysfunctional.

Nature · Feb 23, 2022Peer-reviewedNeuroscience