Author

Edsel M. Abud

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Wayne W. PooniD· 2 shared Alan Edward RentoniD· 1 shared Alice Lau· 1 shared Alison GoateiD· 1 shared Anastasia G. EfthymiouiD· 1 shared Andrea M. Reyes-OrtiziD· 1 shared Corey J. Schulz· 1 shared David Van VactoriD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Wayne W. PoonORCID

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2 papers

Recent·Most cited

Integrated transcriptome analysis of Huntingtons disease iPSC-derived and mouse astrocytes implicates dysregulated synaptogenesis, actin, and astrocyte maturation

Andrea M. Reyes-Ortiz, Edsel M. Abud, Mara S. Burns, Jie Wu, Sarah J. Hernandez, Nicolette R. Geller, Keona Q. Wang, Corey J. Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, Mathew M. Blurton-Jones, David Van Vactor, John C. Reidling, , Leslie Michels Thompson

This study compares HD astrocytes from human iPSCs and mouse models, identifying dysregulated synaptogenesis, actin signaling, and maturation, with unique human findings and potential therapeutic targets.

bioRxiv · Jul 28, 2022 · PreprintNeuroscience

Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanisms

Gloriia Novikova, Edoardo M. Marcora, Manav Kapoor, Julia TCW, Alan Edward Renton, Anastasia G. Efthymiou, Edsel M. Abud, Jaroslav M. Bendl, Haoxiang M. Cheng, John F. Fullard, Panos Roussos, Wayne W. Poon, Ke Hao, Alison Goate

This study integrates Alzheimer’s disease GWAS with myeloid epigenomic data to identify risk enhancers and causal genes, implicating myeloid endolysosomal dysfunction in AD pathogenesis.

Alzheimer s & Dementia · Dec 1, 2020Peer-reviewedGenomics