Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Nadine Huber, Tomi Hietanen, Sami Heikkinen, Anastasia Shakirzyanova, Dorit B. Hoffmann, Hannah Rostalski, Ashutosh Dhingra, Salvador Rodrı́guez-Nieto, Sari Kärkkäinen, Marja Koskuvi, Eila Korhonen, Päivi H. Hartikainen, Katri Pylkäs, Johanna Krüger, Tarja Malm, , Annakaisa Haapasalo
This study shows that iPSC-derived neurons from FTD patients exhibit synaptic dysfunction, DNA damage, and C9-HRE-related pathologies, supporting synaptic dysfunction as a key factor in FTD.
Molecular Psychiatry · Sep 26, 2025Peer-reviewedNeuroscience