Functional Dichotomy of Developmental Foxp3+ Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice
Açelya Yilmazer, Anne Eugster, Dimitra Maria Zevla, Sara Salome Helbich, Marie Boernert, Basak Torun, Elda Marsela, Emre Kirgin, Andreas Dahl, Andreas Petzold, Olivia Kershaw, Vasileia Ismini Alexaki, Antonios Chatzigeorgiou, Michael Delacher, Susan Schlenner, Karsten Kretschmer
This study investigates the functional differences between thymic and peripheral Treg cells in visceral adipose tissue, showing that tTreg instability contributes to inflammation and obesity while pTreg cells protect against metabolic disorders.
bioRxiv · Mar 12, 2025 · PreprintImmunology