MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade efficacy.
Kwang‐Soo Kim, Junyi Zhang, Victor Andrés Arrieta, Crismita Dmello, Elena Grabis, Y Yabo, Si Wang, Karl John Habashy, Joseph Duffy, Junfei Zhao, Andrew Gould, Rishi Jain, Li Chen, JIAN LI HU, Irina V. Balyasnikova, , Adam M. Sonabend
This study identifies the MAPK/ERK pathway as a key regulator of glioma susceptibility to immune checkpoint blockade, showing it modulates interferon responses, T cell recruitment, and tumor-microglia interactions.
Nature Communications · Jun 25, 2026Peer-reviewedCancer Biology