High-throughput micro-patterning platform reveals Nodal-dependent dissection of peri-gastrulation-associated versus pre-neurulation associated fate patterning
Mukul Tewary, Dominika Dziedzicka, Joel Östblom, Laura Prochazka, Nika Shakiba, Tiam Heydari, Daniel Aguilar‐Hidalgo, Curtis M. Woodford, Elia Piccinini, David Becerra‐Alonso, Alice Vickers, Blaise Louis, Nafees Rahman, Davide Danovi, Mieke Geens, , Peter W. Zandstra
The paper develops an in vitro platform to study fate patterning in hPSCs, revealing Nodal-dependent switches between gastrulation and neurulation-associated gene profiles.
PLoS Biology · Oct 21, 2019Peer-reviewedDevelopmental Biology