Elizabeth S. Dean

This study identifies FMO-2's role in promoting longevity in C. elegans by rewiring one carbon metabolism and tryptophan metabolism, linking a single enzyme to metabolic pathways involved in lifespan extension.

The paper identifies compounds that block food perception in C. elegans, increasing longevity by modulating serotonin and dopamine signaling, suggesting a mechanism by which dietary restriction mimetics extend lifespan.