Angela M. Tuckowski

fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans

This study shows that fmo-4 in C. elegans extends lifespan and stress resistance by regulating calcium homeostasis through interactions with known longevity pathways.

A diet of oxidative stress-adapted bacteria improves stress resistance and lifespan in C. elegans via p38-MAPK.

This study shows that C. elegans fed oxidative stress-adapted bacteria live longer and are more stress-resistant due to activation of the p38-MAPK pathway.

FMO rewires metabolism to promote longevity throughtryptophan and one carbon metabolism

This study identifies FMO-2's role in promoting longevity in C. elegans by rewiring one carbon metabolism and tryptophan metabolism, linking a single enzyme to metabolic pathways involved in lifespan extension.

Serotonin and dopamine modulate aging in response to food perception and availability

The paper identifies compounds that block food perception in C. elegans, increasing longevity by modulating serotonin and dopamine signaling, suggesting a mechanism by which dietary restriction mimetics extend lifespan.