Ilse Hofmann

P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy

This paper identifies P2RY2 as a purinergic immune checkpoint that mediates eATP-driven immune evasion and adaptive resistance to immunotherapy by promoting PGE2 accumulation in the tumor microenvironment.

GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer

This study identifies GLYATL1 as a mediator of endocrine resistance in luminal breast cancer by promoting metabolic and epigenetic changes that counteract estrogen deprivation.

EML4-ALK variant-specific genetic interactions shape lung tumorigenesis

The paper investigates functional differences between EML4-ALK variants V1 and V3 in lung cancer using mouse models and human data, showing variant-specific effects on tumorigenesis.

Repurposing passenger amplifications as Trojan horses identifies MPZL1 as a potent target for solid cancers

The paper identifies MPZL1 as a therapeutic target in 1q-amplified solid cancers by repurposing passenger amplifications as Trojan horses for targeted therapy delivery.

Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms

The paper investigates diurnal regulation of IRE-containing mRNAs via IRP1 and IRP2 in mouse liver, showing that feeding rhythms drive rhythmicity even without a functional circadian clock.