MTBP allosterically activates Cdk8-CycC kinase activity
Eman Zaffar, Julio Vieyto‐Nuñez, Katerina Pravi, Mohammed Faidh Aslam, Yasser Almeida‐Hernández, Joel Mieres‐Pérez, Farnusch Kaschani, Markus Kaiser, Anika Kroesen, Dominik Boos, Elsa Sánchez‐García
The paper shows that MTBP allosterically activates Cdk8-CycC kinase activity through distinct mechanisms from Med12, enabling substrate-specific phosphorylation and impacting cancer biology.
bioRxiv · Jun 16, 2025 · PreprintBiochemistry