Characterization of the p38α MAPK allosteric inhibition by a single chain Fv antibody
Emilie Renaud, Marion Larroque, Nicole Bec, Hugo Guérin, Raphaël Sierocki, Corinne Henriquet, Martine Pugnière, Oriane Font, Alexandra Fauvre, Vincent Denis, Céline Gongora, Christian Larroque, Pierre Martineau, Laurence Guglielmi
This paper identifies a single-chain Fv antibody that allosterically inhibits p38α MAPK by binding to a site distinct from the ATP-binding pocket, reducing inflammation in THP-1 cells.
bioRxiv · Jan 6, 2026 · PreprintBiochemistry