Laurence Guglielmi

This paper develops RalA-specific intrabodies that inhibit mitochondrial fission and extracellular vesicle secretion, reducing metastasis in a TNBC mouse model.

This paper identifies a single-chain Fv antibody that allosterically inhibits p38α MAPK by binding to a site distinct from the ATP-binding pocket, reducing inflammation in THP-1 cells.

This study identifies critical parameters for lipid-anchored protein loading into extracellular vesicles and demonstrates efficient intracellular delivery.