Author

Raphaël Sierocki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

Alexandra FauvreiD· 1 shared Andréa Romette· 1 shared Aude Faucon· 1 shared Bastien Serrano· 1 shared Brigitte KerféleciD· 1 shared Céline GongoraiD· 1 shared Christian LarroqueiD· 1 shared Christophe FraisieriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Alexandra FauvreORCID

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Author profile →

2 papers

Recent·Most cited

Characterization of the p38α MAPK allosteric inhibition by a single chain Fv antibody

Emilie Renaud, Marion Larroque, Nicole Bec, Hugo Guérin, Raphaël Sierocki, Corinne Henriquet, Martine Pugnière, Oriane Font, Alexandra Fauvre, Vincent Denis, Céline Gongora, Christian Larroque, Pierre Martineau, Laurence Guglielmi

This paper identifies a single-chain Fv antibody that allosterically inhibits p38α MAPK by binding to a site distinct from the ATP-binding pocket, reducing inflammation in THP-1 cells.

bioRxiv · Jan 6, 2026 · PreprintBiochemistry

Novel VHH targeting a unique TfR1 epitope for efficient cross-species delivery of drugs in the CNS

Marion David, Romy Cohen, Diane Beuzelin, Géraldine Ferracci, Marina Cresci, Aude Faucon, Karima Abouzid, Gersande Godefroy, Maxime Masse, Yasmine Mechioukhi, Stéphane D. Girard, Ingrid Julien‐Gau, Cléa Boursery, Christophe Fraisier, Karine Varini, , Michel Khrestchatisky

This study identifies cross-species reactive VHHs targeting a novel TfR1 epitope, enabling efficient BBB crossing for CNS drug delivery.

Journal of Controlled Release · Oct 17, 2025Peer-reviewedNeuroscience