Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons
Xiao Yi Su, Hanwen Zhang, Hong Yan, Qian Yang, Le Wang, Tiffany T. Le, Jiayi Liu, Lasya Cheruvu, Emily Labour, Siwei Zhang, Karla Méndez‐Maldonado, Anat Kreimer, Hongjun Song, Guo‐li Ming, Jubao Duan, Zhiping P. Pang
This study investigates how rare mutations in the SETD1A gene affect human neurons, showing they disrupt synaptic function and may contribute to schizophrenia pathophysiology.
bioRxiv · Oct 20, 2024 · PreprintNeuroscience