Le Wang

This study compares synaptic effects of NRXN1 deletions in ASD and SCZ iPSC models, finding distinct synaptic and network impairments in ASD.

This study investigates how rare mutations in the SETD1A gene affect human neurons, showing they disrupt synaptic function and may contribute to schizophrenia pathophysiology.

This study identifies dLSGLP-1R neurons and their GABAergic projections to the LHA as regulators of feeding behavior in mice, showing that inhibition of these pathways increases food intake.

This study shows that a specific AAV-Cre preparation causes toxicity in the PVN, leading to metabolic and behavioral changes, independent of genetic background.

The paper investigates the impact of the NLGN3 R451C mutation on human neurons, finding it reduces protein levels but enhances excitatory synapses, potentially contributing to ASD pathogenesis.