Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes
Ujani Chakraborty, Emma Saccone, Grisel Cruz‐Becerra, Laiba F Khan, Nina Arslanovic, Rhiannon R. Aguilar, Susan L. Gloor, Sabrina R. Hunt, Heather J. Folkwein, Natalia Ledo Husby, Keith E. Maier, Matthew R. Marunde, Noah K. Schomburg, Anup Vaidya, Martis W. Cowles, , Jessica K. Tyler
The paper shows that different binding modes to the nucleosome acidic patch lead to distinct cellular outcomes, with overexpression of Dot5 and camelid antibodies causing growth, DNA repair, and heterochromatin defects.
Nucleic Acids Research · Jul 3, 2026Peer-reviewedMolecular Biology