Author

Natalia Ledo Husby

EpiCypher (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:ChIP-seq· 1 Assay:CUT&Tag· 1 Organism:human· 1 Assay:structural biology· 1 Organism:yeast· 1

Frequent Co-Authors

Anup VaidyaiD· 3 shared Keith E. MaieriD· 3 shared Michael‐Christopher KeoghiD· 3 shared Susan L. GlooriD· 3 shared Bryan J. VentersiD· 2 shared Laiba F KhaniD· 2 shared Martis W. CowlesiD· 2 shared Matthew R. MarundeiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Anup VaidyaORCID

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Author profile →

3 papers

Recent·Most cited

Different modes of engagement with the nucleosome acidic patch yield distinct functional outcomes

Ujani Chakraborty, Emma Saccone, Grisel Cruz‐Becerra, Laiba F Khan, Nina Arslanovic, Rhiannon R. Aguilar, Susan L. Gloor, Sabrina R. Hunt, Heather J. Folkwein, Natalia Ledo Husby, Keith E. Maier, Matthew R. Marunde, Noah K. Schomburg, Anup Vaidya, Martis W. Cowles, , Jessica K. Tyler

The paper shows that different binding modes to the nucleosome acidic patch lead to distinct cellular outcomes, with overexpression of Dot5 and camelid antibodies causing growth, DNA repair, and heterochromatin defects.

Nucleic Acids Research · Jul 3, 2026Peer-reviewedMolecular Biology

Nucleosome context regulates chromatin reader preference

Matthew R. Marunde, Irina K Popova, Nathan W Hall, Anup Vaidya, James R. Bone, Brandon A. Boone, Peter J. Brown, Ryan J. Ezell, Tessa M. Firestone, Harrison A. Fuchs, Elisa Gibson, Zachary B Gillespie, Susan L. Gloor, Allison R. Hickman, Sarah A Howard, , Jonathan M. Burg

The paper investigates how nucleosome context influences chromatin reader binding preferences using biochemical and genomic approaches, revealing that multivalent engagement often has regulatory effects beyond simple additivity.

Nucleic Acids Research · Oct 1, 2025Peer-reviewedBiochemistry

Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch

Chad W. Hicks, Sanim Rahman, Susan L. Gloor, James K. Fields, Natalia Ledo Husby, Anup Vaidya, Keith E. Maier, Michael Thomas Morgan, Michael‐Christopher Keogh, Cynthia Wolberger

This study reveals that H2BK120ub blocks the nucleosome acidic patch, preventing protein binding, while H2AK119ub does not, highlighting distinct roles of these ubiquitinations in chromatin regulation.

Nucleic Acids Research · Aug 1, 2024Peer-reviewedBiophysics