ImmunologyiSciencePeer-reviewed
Small molecule inhibitor binds to NLRP3 and prevents inflammasome activation
Angela Lackner, Julia Elise Cabral, Yanfei Qiu…·Reginald McNulty
The paper identifies that NLRP3 binds and cleaves oxidized DNA, and small molecule drugs inhibit this process to prevent inflammasome activation.
16 citations