Sophia Lin

Acute in vivo proximity labeling for membrane targeted proteomics in neuronal circuits

The paper develops membrane-targeted TurboID variants for in vivo proteomics in neuronal circuits, identifying subcellular proteins and their changes during acute drug exposure.

NLRP10 Cleaves Oxidized DNA inhibited by OGG1 inhibitors: A Newly Identified Role in DNA Damage Processing and Senescence Regulation.

This study identifies NLRP10's role in cleaving oxidized DNA and its impact on senescence and inflammasome activation through interactions with NLRP3.

Rapid, biochemical tagging of cellular activity history in vivo

This paper introduces CaST, a method to biochemically tag cells with elevated Ca2+ in vivo, and demonstrates its use in tagging prefrontal cortex neurons activated by psilocybin in mice.

Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures

The paper determines the fractional block of Nav channels needed to impair neuronal excitability and reduce seizure-like activity using TTX in pyramidal neurons.