Author

Angela Lackner

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1

Frequent Co-Authors

Reginald McNultyiD· 3 shared Karen Wang· 2 shared Sofia I. PicucciiD· 2 shared Valerie Henriquez· 2 shared Alijah Macapagal· 1 shared Camille AndréiD· 1 shared Eric M. PearlmaniD· 1 shared George DubyakiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

Reginald McNultyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950

Angela Lackner, Sofia I. Picucci, Wenjin Jiang, Janset Onyuru, Melissa Campos, Julia Elise Cabral, Lemuel Leonidas, Alijah Macapagal, Hannah J. Lee, Valerie Henriquez, Karen Wang, Huilin Xu, Yanfei Qiu, Lauren Veronica Albrecht, Hal M. Hoffman, Reginald McNulty

This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.

Communications Biology · Apr 16, 2026Peer-reviewedImmunology

Alpha hemolysin polymorphisms in methicillin-resistant Staphylococcus aureus clinical isolates regulate ADAM10-dependent neutrophil IL-1 beta secretion

Karl Liboro, Jolynn Tran Chau, James D Begando, Serena Abbondante, Angela Lackner, Yan Sun, Michaela Ellen Marshall, Nikitina Ly, Victor D. Johnson, George Dubyak, Michael S. Gilmore, Reginald McNulty, Camille André, Eric M. Pearlman

The paper shows that Hla polymorphisms in MRSA strains affect ADAM10-dependent neutrophil IL-1β secretion and corneal disease severity.

bioRxiv · Dec 14, 2025 · PreprintMicrobiology

RM1mAb avoids Intracellular degradation to Synergistically inhibit NLRP3 Inflammasome Activation in Familial Cold Autoinflammatory Syndrome

Angela Lackner, Sofia I. Picucci, Valerie Henriquez, Karen Wang, Reginald McNulty

RM1mAb and TH5487 synergistically inhibit inflammasome activation in human FCAS PBMCs by preventing NLRP3-mtDNA interaction and avoiding lysosomal degradation.

bioRxiv · Dec 12, 2025 · PreprintImmunology