Author

Alijah Macapagal

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Angela Lackner· 1 shared Hal M. HoffmaniD· 1 shared Hannah J. LeeiD· 1 shared Huilin XuiD· 1 shared Janset OnyuruiD· 1 shared Julia Elise CabraliD· 1 shared Karen Wang· 1 shared Lauren Veronica AlbrechtiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Angela Lackner

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1 paper

Recent·Most cited

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950

Angela Lackner, Sofia I. Picucci, Wenjin Jiang, Janset Onyuru, Melissa Campos, Julia Elise Cabral, Lemuel Leonidas, Alijah Macapagal, Hannah J. Lee, Valerie Henriquez, Karen Wang, Huilin Xu, Yanfei Qiu, Lauren Veronica Albrecht, Hal M. Hoffman, Reginald McNulty

This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.

Communications Biology · Apr 16, 2026Peer-reviewedImmunology