Author
University of California, IrvineORCID 0000-0003-2101-1377Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Angela Lackner, Sofia I. Picucci, Wenjin Jiang…·Reginald McNulty
This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.
Karl Liboro, Jolynn Tran Chau, James D Begando…·Eric M. Pearlman
The paper shows that Hla polymorphisms in MRSA strains affect ADAM10-dependent neutrophil IL-1β secretion and corneal disease severity.
Angela Lackner, Sofia I. Picucci, Valerie Henriquez…·Reginald McNulty
RM1mAb and TH5487 synergistically inhibit inflammasome activation in human FCAS PBMCs by preventing NLRP3-mtDNA interaction and avoiding lysosomal degradation.
Julia Elise Cabral, Sophia Lin, Haitian Zhou…·Reginald McNulty
This study identifies NLRP10's role in cleaving oxidized DNA and its impact on senescence and inflammasome activation through interactions with NLRP3.
Angela Lackner, Julia Elise Cabral, Yanfei Qiu…·Reginald McNulty
The paper identifies that NLRP3 binds and cleaves oxidized DNA, and small molecule drugs inhibit this process to prevent inflammasome activation.