Ángel Núñez

Convergent pathways with impaired inhibition at the frontal cortex are the outcome of differential alterations in the male and female schizophrenia model

This study identifies sex-specific molecular and functional changes in a schizophrenia model, revealing convergent inhibitory deficits through divergent pathways.

INSULIN-LIKE GROWTH FACTOR I SENSITIZATION REJUVENATES SLEEP PATTERNS IN OLD MICE

This study shows that IGF-I signaling to orexin neurons is impaired in old mice, leading to sleep disturbances, and that IGF-IR sensitizer AIK3a305 restores sleep patterns.

Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy

This study shows that reducing NOX4 in neurons alleviates tau-related pathology and cognitive decline in a mouse model of tauopathy.

Insulin-Like Growth Factor I Modulates Sleep Through Hypothalamic Orexin Neurons

This study shows that IGF-I modulates sleep by regulating orexin neurons in the hypothalamus, affecting sleep architecture and electrocorticographic patterns in mice.

Thalamic encoding of complex sensory patterns and its possible role in cognition

This study investigates the role of the POm nucleus in encoding complex sensory patterns and its potential involvement in cognitive functions through a functional loop with the cortex.

IGF-I Governs Cortical Inhibitory Synaptic Plasticity By Astrocyte Activation

This study shows that IGF-I signaling in astrocytes regulates inhibitory synaptic plasticity and behavior by inducing LTD through ATP/adenosine release and A2A receptor activation.