3-hydroxyanthranilic acid - a new metabolite for healthy lifespan extension
Hope T. L. Dang, Raúl Castro-Portuguez, Luis S. Espejo, Grant Backer, Samuel Freitas, Erica Spence, Jeremy Meyers, Karissa Shuck, Caroline Corban, Teresa Liu, Shannon Bean, Susan Sheehan, Ron Korstanje, George L. Sutphin
This study identifies 3-hydroxyanthranilic acid (3HAA) as a metabolite that extends lifespan and improves health in C. elegans and mice by reducing oxidative stress and activating the Nrf2/SKN-1 pathway.
bioRxiv · Jun 1, 2021 · PreprintMolecular Biology