Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
Ghazaleh Eskandari‐Sedighi, Madeline C. Crichton, Sameera Zia, Erik Gomez, Chris D. St. Laurent, Leonardo M. Cortez, Zain H. Patel, Gaurav Sidhu, Susmita Sarkar, Vivian Aghanya, Valerie L. Sim, Qiumin Tan, Olivier Julien, Jason R. Plemel, Matthew Scott Macauley
This study shows that human CD33 isoforms differentially affect microglial responses in Alzheimer's disease, with CD33m showing protective effects against amyloid-beta pathology.
bioRxiv · Jul 4, 2023 · PreprintNeuroscience