Early defects in lysosomal storage diseases disrupt excitatory synaptic transmission
Camila De Britto Pará De Aragão, Luigi Bruno, Poulomee Bose, Xuefang Pan, Chanshuai Han, Peter Scottt McPherson, Erika Freemantle, Jean‐Claude Lacaille, Éric Bonneil, Pierre Thibault, Claire O’Leary, Brian Bigger, Carlos Ramón Morales, Graziella Di Cristo, Alexey V. Pshezhetsky
This study shows that lysosomal storage diseases cause synaptic structure and neurotransmission defects before cognitive symptoms appear in mice and humans.
bioRxiv · Jul 6, 2020 · PreprintNeuroscience