Pierre Thibault

Tumour-stroma signaling drives a reversible program with neural-like features in cancer-associated fibroblasts

The paper identifies tumor-derived signals that induce a reversible neural-like program in cancer-associated fibroblasts and shows it is regulated by growth factors and MAPK/ERK signaling.

Mice with mono-allelic p.R37H Dhdds variant show aberrant glycosylation and interneuron deficits

This study describes a mouse model of DHDDS-CDG, showing seizures, myoclonus, and cognitive deficits linked to glycosylation defects and interneuron abnormalities.

STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation.

The paper shows STING dampens the unfolded protein response to allow self-antigen presentation on MHC-I during inflammation, linking it to immune regulation in Parkinson's disease.

LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death

The paper shows LRRK2 mutations impair NCOA4 trafficking during iron overload, causing ferroptotic cell death in macrophages.

Synthetic analogue of adrenocorticotropic hormone, ACTH(4-7)PGP delays neurological manifestations in diseases of mucopolysaccharidosis III spectrum by reducing neuroinflammation and rescuing neurotransmission, synaptogenesis, and axonal demyelination

The paper tests a synthetic peptide ACTH(4-7)PGP in MPS III mouse models, showing it improves synaptic function, reduces neuroinflammation, and extends lifespan.

Redundant roles of YES and SRC tyrosine kinases in driving malignant peripheral nerve sheath tumors

This study identifies YES and SRC tyrosine kinases as redundant drivers of MPNST and shows their inhibition suppresses tumor growth and reactivates immune responses.

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis

This study shows FOXK1 O-GlcNAcylation regulates the E2F pathway, promoting cell proliferation and oncogenesis by modulating chromatin structure and transcriptional activity.

Enriching for Extracellular Vesicles from Human Bone

This study introduces a new protocol to isolate and enrich extracellular vesicles from human trabecular bone and bone marrow without enzymatic digestion or long-term culture.

Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis

This study identifies Ankle2 as a regulatory subunit of PP2A that promotes BAF dephosphorylation and nuclear reassembly by interacting with Vap33 during telophase.

Comprehensive Proteomic Analysis of HCoV-OC43 Virions and Virus-Modulated Extracellular Vesicles

This study identifies host proteins incorporated into HCoV-OC43 virions and virus-modulated extracellular vesicles, revealing their roles in viral spread and extracellular vesicle composition.

SPAT: Surface Protein Annotation Tool

SPAT annotates proteins based on their likelihood to be at the cell surface using existing annotations, showing good performance on leukemia and public datasets.

Immunopeptidomics for Dummies: Detailed Experimental Protocols and Rapid, User-Friendly Visualization of MHC I and II Ligand Datasets with MhcVizPipe

The paper provides detailed experimental protocols and an open-source tool, MhcVizPipe, for analyzing MHC I and II ligand datasets in immunopeptidomics.

Early defects in lysosomal storage diseases disrupt excitatory synaptic transmission

This study shows that lysosomal storage diseases cause synaptic structure and neurotransmission defects before cognitive symptoms appear in mice and humans.

CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation

The paper introduces CAMAP, an artificial neural network that predicts MHC-I peptide presentation by analyzing codon arrangement in mRNA sequences, improving prediction accuracy beyond traditional methods.