Rewiring DNA repair with PARP-based chemical inducers of proximity
Bryce da Camara, Eric M. Bilotta, Erin Broderick, Ashwini Premashankar, Paige A. Barta, Trever R. Carter, Lauren M. Hargis, Daniel Durocher, Michael A. Erb
This paper develops PCIP-1, a PARP-based chemical inducer of proximity that rewires DNA repair by recruiting BET proteins to PARP2, showing synthetic lethality in cancer cells with homologous recombination deficiencies.
bioRxiv · Jul 26, 2025 · PreprintCancer Biology