A DNA tension-dependent tug-of-war between dimeric SMC motors governs loop extrusion directionality
Biswajit Pradhan, Adrian Pinto, Damla Tetiker, Takaharu Kanno, Gemma L. M. Fisher, Martin Dieter Baaske, Erin Cutt, Constantinos Chatzicharlampous, Herwig Schuler, Amar Deep, Kevin D. Corbett, Luís Aragón, Peter Virnau, Camilla Björkegren, Eugene Kim
This study shows that dimeric SMC motors switch extrusion directionality based on DNA tension, with cohesin being constitutively biased toward one-sided extrusion.
bioRxiv · Sep 12, 2024 · PreprintBiophysics